Molecular Pathways That Mediate 2 Gehgdei Alt~ L Transduction and Transcription: Lessons Learned from Stats. (65) Pnor Pubhcatlon Data Binding Protein-1, and Igf Binding Protein-3 Concentration in The
نویسنده
چکیده
NERVOUS SYSTEM PLASTICITY ’ ’ °e e e a ' 5,728,566 A 3/1998 Goeddel et al. (75) IHVBIIIOFSI Mriganka Sun Cambridge, MA (Us); 5,753,486 A 5/ 1998 Goeddel et al. Daniela Tropea, Cambridge, MA (US); 5,770,426 A 6/ 1998 Anderson et al. Gabriel Kreiman, West Newton, MA 5,797,898 A 8/1998 sannnl et al~ (Us) 5,846,565 A 12/1998 Brem et al. 5,861,373 A * 1/1999 Gl km t l. ........... .. 514/86 (73) Assignee: Massachusetts Institute of Technology, 5,369,314 A 2/1999 Goiideflgtifl Cambridge, MA (US) 6,129,761 A 10/2000 Hubbell
منابع مشابه
Investigation on the Levels of IGF-I Receptor and IGF-I Binding Protein I in the Brain of Insulin Resistant Rats
Abstract Introduction: There is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor (IGF-I) to transduce the signals in different areas of the brain. In this article we aimed at investigating whether the expression of IGF-I receptor and IGF-I binding proteins (IGFBP1) is change...
متن کاملStudy of PKA binding sites in cAMP-signaling pathway using structural protein-protein interaction networks
Backgroud: Protein-protein interaction, plays a key role in signal transduction in signaling pathways. Different approaches are used for prediction of these interactions including experimental and computational approaches. In conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins inter...
متن کاملIn vivo regulation of growth hormone-stimulated gene transcription by STAT5b.
The long-term effects of growth hormone (GH) are mediated through coordinated changes in gene expression that are the outcome of interactions between hormone-activated signal transduction pathways and specific feedback loops. Recent studies in mice have implicated the transcription factor STAT5b as part of the GH-regulated somatic growth pathway, because mice lacking this protein showed diminis...
متن کاملChemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2.
Insulin-like growth factor 2 (IGF2) is a potent mitogen whose deregulation plays a role in developing liver, breast, and prostate cancers. Here, we take a small-molecule approach to investigate molecular pathways that modulate IGF2 signaling, by using chromeceptin, a synthetic molecule that selectively impairs the viability and growth of IGF2-overexpressing hepatocellular carcinoma cells. Affin...
متن کاملEffects of feed restriction and dietary fat type on mRNA expression of liver fatty acid-binding protein (L-FABP) in broilers
Background: Liver fatty acid-binding protein (L-FABP) is the main cytosolic binding site for long chain fatty acids in hepatocytes. FABPs enhance the uptake of fatty acids into the cell by increasing their concentration due to decreasing concentration of unbound fatty acids inside the cell. Objectives: The aim of this study was to evaluate the effects of dietary unsaturated to saturated fatty a...
متن کامل